"KnockKnock... Who's There?" See what's persistently installed on your Mac. KnockKnock uncovers persistently installed software in order to generically reveal malware.
TaskExplorer allows one to visually explore all running tasks (processes). Quickly see a task's signature status, loaded dylibs, open files, network connection, and much more.
BlockBlock provides continual protection by monitoring persistence locations. Any new persistent component will trigger a BlockBlock alert, allowing malicious items be blocked.
By continually monitoring the file-system for the creation of encrypted files by suspicious processes, RansomWhere? aims to protect your personal files, generically stopping ransomware in its tracks.
Mac malware often spies on users by recording audio and video sessions...sometimes in an undetected manner.
OverSight monitors a mac's mic and webcam, alerting the user when the internal mic is activated, or whenever a process accesses the webcam.
Ostiarius is tool for El Capitan that blocks unsigned internet binaries from executing. Though OS X's Gatekeeper attempts provide this functionality, it's trivial to bypass.